If you are opening Design Manager Cloud Applications for the first time using Google Chrome as your Internet Browser,  follow the steps below:

Right-click and choose Settings on the far right corner of the browser window.

Search for "Plug" and it will be located under Content Settings and Unsandboxed Plug-in Access

Add Cloud.designmanager.com to Allowed plugins and choose Add

You gave now granted Citrix permission to launch from the Design Manager website.

The next time you launch the application from the icon, it should automatically begin to load and you should not need to set the plug-in permissions.